α-Conotoxin MII( —— )

Catalog No. M23790 CAS No. 175735-93-0

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Datasheet

HNMR

HPLC

MSDS

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Product Name

α-Conotoxin MII
Note

Research use only, not for human use.
Brief Description

α-Conotoxin MII is a highly potent and selective competitive antagonist for α3β2 subunit-containing nicotinic receptors.
Description

α-Conotoxin MII is a highly potent and selective competitive antagonist for α3β2 subunit-containing nicotinic receptors (IC50 = 0.5 - 3.5 nM at α3β2 expressed in Xenopus oocytes). Also potently blocks β3-containing neuronal nicotinic receptors. Displays > 200-fold selectivity for α3β2 over α2β2, α4β2 and α3β4.
In Vitro

α-Conotoxin MII (0.5-3.5 nM) blocks ACh responses in oocytes expressing α3β2 nicotinic acetylcholine receptors.
In Vivo

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Synonyms

——
Pathway

Endocrinology/Hormones
Target

AChR
Recptor

α3β2 nAChR
Research Area

——
Indication

——

CAS Number

175735-93-0
Formula Weight

1710.99
Molecular Formula

C67H103N23O22S4
Purity

>98% (HPLC)
Solubility

water:1 mg/mL
SMILES

Gly-Cys-Cys-Ser-Asn-Pro-Val-Cys-His-Leu-Glu-His-Ser-Asn-Leu-Cys-NH2 (Disulfide bridge:Cys2-Cys8;Cys3-Cys16)
Chemical Name

——

1.Cartier et al (1996) A new α-conotoxin which targets α3β2 nicotinic acetylcholine receptors. J.Biol.Chem. 271 7522 PMID:

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